The Protective Effects of Tea Polyphenols in Rat,Renal Ischemia Reperfusion Injury Models

Objective:To explore the protective mechanism of tea polyphenols on renal ischemia reperfusion injury (IRI) rats models.Methods:42 SD male rats were randomly divided into 3 groups:Sham-operated group (group S),renal ischemia reperfusion injury group (group IRI) and tea polyphenols precondiontioning group (group TP).Among them,the rats in group IRI and TP were made IRI models by operation. However,the TP group were treated by TP while the group IRI were't.The levels of Scr,serum super oxide dimutase (SOD),serum mlondialdehyde (MDA),renal tissue's SOD and MDA in each group were detected respectively at the time of 0 minute,2 hours and 24 hours after renal ischemia reperfusion (RIR) happened.Pathological changes were also noted by light microscope.Results:After renal ischemia reperfusion the renal histopathological changes of group TP were much less than group IRI (P0.05),moreover,Scr was also lower than it of IRI group (P0.05).Compare with group S,the levels of Scr and MDA in group IRI increased significantly while the SOD in serum and kidney tissue decreased.But in group TP,the levels of Scr and MDA,whatever in serum or in kidney tissue,were all lower than that in group IRI,while the levels of SOD were higher.There were statistic difference between the serum levels of SOD,MDA and renal tissue's SOD,MDA in two groups (P0.05).Conclusion:Tea polyphenols could protect the kidney against renal ischemia reperfusion injury.That might be realized by its antioxidation.