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2006•Chinese Journal of Birth Health & HeredityRequires access

Effects of recombinant human growth hormone on height in Turner syndrome.

Qiu Ding

Open publisher page 1 citations

Abstract

Objective: To evaluate the effect of the recombinant human Growth hormone (rhGH) therapy on height velocity in patients with Turner syndrome. Methods: 30 Turner syndrome ( age12. 5±3.76 years, bone age 10. 6±2. 49years) received rhGH 0. 13IU · kg-1·d-1, they were Karyotyped and growth hormone provocation tests. Results: The effects of rhGH increasing the linear growth is significant (P 0. 001), height velocity (HV) increased from 2. 46 ± 0. 78 cm/year (before treatment) to 7. 25 ± 1. 68cm/ year (after treatment one year) , the differences is highly significant (P 0. 001). Height added 0. 73SDS. Conclusion: rhGH had obvious result in promoted the growth in Turner syndrome.

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What this paper is about

Objective: To evaluate the effect of the recombinant human Growth hormone (rhGH) therapy on height velocity in patients with Turner syndrome. Methods: 30 Turner syndrome ( age12. 5±3.76 years, bone age 10. 6±2. 49years) received rhGH 0. 13IU · kg-1·d-1, they were Karyotyped and growth hormone provocation tests. Results: The effects of rhGH increasing the linear growth is significant (P 0. 001), height velocity (HV) increased from 2. 46 ± 0. 78 cm/year (before treatment) to 7. 25 ± 1. 68cm/ year (after treatment one year) , the differences is highly significant (P 0. 001). Height added 0. 73SDS. Conclusion: rhGH had obvious result in promoted the growth in Turner syndrome.

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Available abstract

Objective: To evaluate the effect of the recombinant human Growth hormone (rhGH) therapy on height velocity in patients with Turner syndrome. Methods: 30 Turner syndrome ( age12. 5±3.76 years, bone age 10. 6±2. 49years) received rhGH 0. 13IU · kg-1·d-1, they were Karyotyped and growth hormone provocation tests. Results: The effects of rhGH increasing the linear growth is significant (P 0. 001), height velocity (HV) increased from 2. 46 ± 0. 78 cm/year (before treatment) to 7. 25 ± 1. 68cm/ year (after treatment one year) , the differences is highly significant (P 0. 001). Height added 0. 73SDS. Conclusion: rhGH had obvious result in promoted the growth in Turner syndrome.

Key concepts: Turner syndrome, Human growth hormone, Provocation test, Turner's syndrome, Growth hormone, Medicine, Recombinant DNA, Bone age

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