Investigation on the relationship between positive thyroid antibody of pregnant women and thyroid stimulating hormone of neonates in high water iodine area

Objective:To explore the change of thyroid function of pregnant women with positive thyroid antibody and the relationship between positive thyroid antibody of pregnant women and thyroid stimulating hormone(TSH) of neonates in high water iodine area. Methods:Jinghai maternal and child health hospital in Tianjin in high water iodine area(iodine level in drinking water200 μg/L) and maternal and child health hospital of Heping district in Tianjin in appropriate iodine area(iodine level in drinking water10 μg/L,popularizing rate of iodized salt90%,median of urine iodine100 μg/L) were selected as investigation sites.50 pregnant women during the first trimester of pregnancy,50 pregnant women during the second trimester of pregnancy and 50 pregnant women during the third trimester of pregnancy were selected from outpatient department of the hospital with intact data,all the study objects were healthy,without the history of thyroid diseases,their age was during 20～40 years.The indexes of thyroid function(including TSH,total thyroxine 4,free thyroxine 4,total thyroxine 3,free thyroxine 3,triglyceride)in blood samples were detected.115 neonates born by 115 investigated pregnant women were selected from high water iodine area,the level of TSH in their heel blood was detected. Results:The level of TSH in pregnant women with positive thyroid antibody was significantly higher than that in pregnant women with negative thyroid antibody,but their triglyceride level was significantly lower than that in pregnant women with negative thyroid antibody.The detection rate of TSH≥5 IU/ml in neonates born by pregnant women with positive thyroid antibody was higher than that in neonates born by pregnant women with negative thyroid antibody,but there was no significant difference(3/10 vs 8/98,P=0.064). Conclusion:The pregnant women with positive thyroid antibody maybe have subclinical hypothyroidism,and the level of TSH in their neonates may increase easily.Triglyceride,TSH and thyroid antibody can be used as indexes to monitor the thyroid functions of pregnant women and their neonates.