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2014•Journal of Clinical Pulmonary MedicineRequires access

Changes of MMP-9 in exhaled breath condensate of patients with obstructive sleep apnea hypopnea syndrome

Jia Xu

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Abstract

Objective To evaluate the changes of matrix metalloproteases-9( MMP-9) in exhaled breath condensate( EBC) with Obstructive sleep apnea-hypopnea syndrome( OSAHS). Methods Select 40 males and OSAHS patients for the experimental group,30 healthy subjects matched age and body mass index as a control group. exhaled breath condensate The levels of MMP-9 in EBC were determined by ELISA. Results Compared to the control group,the MMP-9 in OSAHS group was significantly higher( P 0. 05). MMP-9 was positively correlated with AHI( P 0. 05),and negative correlated the lowest SaO2( P 0.05). Conclusion The MMP-9 levels in EBC in OSAHS patients may reflect the severity of OSAHS.

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What this paper is about

Objective To evaluate the changes of matrix metalloproteases-9( MMP-9) in exhaled breath condensate( EBC) with Obstructive sleep apnea-hypopnea syndrome( OSAHS). Methods Select 40 males and OSAHS patients for the experimental group,30 healthy subjects matched age and body mass index as a control group. exhaled breath condensate The levels of MMP-9 in EBC were determined by ELISA. Results Compared to the control group,the MMP-9 in OSAHS group was significantly higher( P 0. 05). MMP-9 was positively correlated with AHI( P 0. 05),and negative correlated the lowest SaO2( P 0.05). Conclusion The MMP-9 levels in EBC in OSAHS patients may reflect the severity of OSAHS.

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Available abstract

Objective To evaluate the changes of matrix metalloproteases-9( MMP-9) in exhaled breath condensate( EBC) with Obstructive sleep apnea-hypopnea syndrome( OSAHS). Methods Select 40 males and OSAHS patients for the experimental group,30 healthy subjects matched age and body mass index as a control group. exhaled breath condensate The levels of MMP-9 in EBC were determined by ELISA. Results Compared to the control group,the MMP-9 in OSAHS group was significantly higher( P 0. 05). MMP-9 was positively correlated with AHI( P 0. 05),and negative correlated the lowest SaO2( P 0.05). Conclusion The MMP-9 levels in EBC in OSAHS patients may reflect the severity of OSAHS.

Key concepts: Medicine, Exhaled breath condensate, Obstructive sleep apnea, Hypopnea, Internal medicine, Apnea–hypopnea index, Gastroenterology, Matrix metalloproteinase

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