Immune tolerance induction by IL-10 modified dendritic cells in rat small bowel transplantation

Objective To study the effect of allograft immune tolerance induction by donor IL-10-modified dendritic cells (DC)for providing theoretical and practical basis for anti-rejection of small bowel transplantation. Methods The recipient was pretreated with donor IL-10-treated DC or with untreated DC. Small bowel transplantation was performed and the survival time of small bowel allografts were observed. Results The survival time in the groups of control, untreated DC and IL-10-treated DC was ( 7.33 ± 2.42 ) days, ( 8.33 ± 2.94 ) days and ( 18.5 ± 5.17 ) days respectively. Statistical analysis showed that there was no obvious difference between untreated DC and control groups. However, the survival time of small bowel allografts in IL-10-treated DC group was significantly different from that in control group ( P 0.01 ).Conclusion The pretreatment with donor IL-10-treated DC can prolong the survival time of rat small bowel allografts after transplantation.