Clinical significance of serum CA125 in patients with pleural effusion

Objective To study the concentration of serum CA125 in patients with pleural effusion caused by various diseases,and to explore the clinical value of serum CA125 to patients with pleural effusion. Methods 130patients were selected,and their serum levels of CA125 were detected. The patients were divided into different groups according benign or malignant,volume,exudate and transudate. The differences of CA125 was analyzed among those groups. Results The serum level of CA125 increased in 123 patients,and the positive rate was 94. 62%. The serum level of CA125 in patients with malignant pleural effusion was significantly higher than that in benign pleural effusion( P 0. 05),but there were no significant difference between large and small intermedia volume of pleural effusion,and exudate and transudate( P 0. 05). Conclusion The positive rate of serum CA125 in patients with pleural effusion is considerably high,and it can predict that the inspection of serum CA125 has significantly clinical value for the diagnosis and differential diagnosis of pleural effusion. But it has nothing to do with the volume of pleural effusion and exudate and transudate.