2007•Jiepou kexue jinzhanRequires access
Coincident Distribution of ZnT3 and Aβ in the Cerebral Vessels and Choroid Plexus of APP/PS1 Transgenic Mouse
Wang Zhan-you
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Abstract
Object To investigate the localizations of zinc transporter 3(ZnT3) andβ-amyloid protein(Aβ)in the cerebral vessels and choroid plexus of APP/PS1 transgenic mouse and to explore the possible role of ZnT3 in AD pathogenesis. Methods Immunofluorescence and confocal laser scanning microscopy were used to analyze the coincident distribution of ZnT3 and Aβ in the cerebral vessels and choroid plexus of APP/PS1 transgenic mouse. Results In the APP/PS1 transgenic mouse, the epithelial cells of choroid plexus of the lateral, third, and fourth ventricles presented both Aβ and ZnT3 positive immunoreactivity in the cytoplasm, but absent in the nucleus. ZnT3 immunoreactivity was also observed in almost all the Aβ-positive wall of blood vessels. Conclusion The coincident distributions of ZnT3 and Aβ immunoreactivity in the cerebral vessels and choroid plexus suggest that ZnT3 may be involved in the deposition of Aβ in the cerebral vessels and choroid plexus.