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2011•Shanghai Journal of Traditional Chinese MedicineRequires access

Research advance in tetrandrine's inhibition action on multidrug resistance

Zhen Hong

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Abstract

This paper summarizes the mechanisms of multidrug resistance(MDR) and the probable mechanism of the tetrandrine's inhibition action on MDR.The possible mechanisms include: inhibiting the function of P-glycoprotein,inducing cell apoptosis,decreasing the activity of protein kinaseC(PKC),influencing the expression of nuclear factor kappaB and the level of intracellular calcium.

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What this paper is about

This paper summarizes the mechanisms of multidrug resistance(MDR) and the probable mechanism of the tetrandrine's inhibition action on MDR.The possible mechanisms include: inhibiting the function of P-glycoprotein,inducing cell apoptosis,decreasing the activity of protein kinaseC(PKC),influencing the expression of nuclear factor kappaB and the level of intracellular calcium.

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Available abstract

This paper summarizes the mechanisms of multidrug resistance(MDR) and the probable mechanism of the tetrandrine's inhibition action on MDR.The possible mechanisms include: inhibiting the function of P-glycoprotein,inducing cell apoptosis,decreasing the activity of protein kinaseC(PKC),influencing the expression of nuclear factor kappaB and the level of intracellular calcium.

Key concepts: Tetrandrine, Medicine, Multiple drug resistance, Mechanism of action, Pharmacology, Intracellular, Apoptosis, Protein kinase C

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