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2008•Chinese Journal of HemorheologyRequires access

The Effectiveness of Splenectomy in Patients with Idiopathic Thrombocytopenic Purpura

Daoxiong Lei

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Abstract

Objective To investigate the effectiveness of splenectomy in patients with idiopathic thrombocytopenic purpura who failed to respond to conservative management.Method Fifty-eight patients were treated with splenectomy and the clinical outcome was observed.Results Platelet count recovered to normal (≥10×109/L) one week after operation in 45 cases(77.6%).The total effective rate was 75.6% when followed-up for 2 months, 80% when tbliowed-up for 6 months and 10 cases had recurrence.Conclusions Splenectomy is a safe and effective therapy for patients with ITP who failed to respond to conservative therapy and those who had an early increase of platelet count after operation have better prognosis.

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What this paper is about

Objective To investigate the effectiveness of splenectomy in patients with idiopathic thrombocytopenic purpura who failed to respond to conservative management.Method Fifty-eight patients were treated with splenectomy and the clinical outcome was observed.Results Platelet count recovered to normal (≥10×109/L) one week after operation in 45 cases(77.6%).The total effective rate was 75.6% when followed-up for 2 months, 80% when tbliowed-up for 6 months and 10 cases had recurrence.Conclusions Splenectomy is a safe and effective therapy for patients with ITP who failed to respond to conservative therapy and those who had an early increase of platelet count after operation have better prognosis.

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Available abstract

Objective To investigate the effectiveness of splenectomy in patients with idiopathic thrombocytopenic purpura who failed to respond to conservative management.Method Fifty-eight patients were treated with splenectomy and the clinical outcome was observed.Results Platelet count recovered to normal (≥10×109/L) one week after operation in 45 cases(77.6%).The total effective rate was 75.6% when followed-up for 2 months, 80% when tbliowed-up for 6 months and 10 cases had recurrence.Conclusions Splenectomy is a safe and effective therapy for patients with ITP who failed to respond to conservative therapy and those who had an early increase of platelet count after operation have better prognosis.

Key concepts: Splenectomy, Medicine, Thrombocytopenic purpura, Surgery, Platelet, Conservative treatment, Purpura (gastropod), Internal medicine

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