Analysis of immunophenotyping characteristics and clinical prognosis of 108 patients with acute myeloid leukaemia

Objective To evaluate the impact of immunophenotyping on diagnosis and prognosis of acute myeloid leukaemia(AML).Methods Flow cytometry(FCM) was used to detect the immunophenotype of bone marrow in 108 patients with primary AML.Results ①Of AML patients,the expression rates of antigens were mainly CD33(96.3%),CD13(88.0%) and MPO(88.0%) in bone mallow.Notably,CD38 was most commonly seen in hematopoietic stem /progenitor of antigen,being 95.4%.②There were 52.8%(57/108) AML patients had expressions of lymphoid-associated antigen,mainly CD19(23.1%),CD7(21.3%) and CD4(17.6%).③Among 3 groups of AML pa-tients in high,moderate and low risk degrees,the lymphoid antigen expressions of CD4 and CD7 in low risk group were lower than those in moderate and high risk group(both P0.01),which was on contrary to the expression of CD19(both P0.05).Conclusion The immunophenotyping played an important role in diagnosis and prognosis of AML.