2012•Zhongguo laonianxue zazhiRequires access

Effect of Moxibustion pretreatment on the expression of brain-derived neurotrophic factor and its receptor TrkB in hippocampus CA1 region of rats with Alzheimer′s disease

Sun Guo

Abstract

Objective To investigate the mechanism of Moxibustion pretreatment in prevention and cure of Alzheimer′s disease(AD).Methods Rats were randomly divided into normal,sham,model and moxibustion pretreatment groups(n=10).AD rats were induced by injecting β-amyloid25~35(Aβ25~35) into the double hippocampus.Bǎihui,Shenshū and Zusānlǐ acupoints were used to prevent and cure AD by moxibustion.Brain-derived neurotrophic factor(BDNF) and its receptor TrkB in hippocampus CA1 zone of rats were detected by immunohistochemistry.Results Compared with normal and sham group,the expression of BDNF and its receptor TrkB in model group were significantly decreased(P0.01).Compared with the model group,the expressions of BDNF and TrkB in moxibustion pretreatment group were significantly increased(P0.01).Conclusions Moxibustion pretreatment could effectively increase the expressions of BDNF and TrkB in hippocampus CA1 zone,ameliorate the neuron injury of the brain and protect the brain cells.

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Key concepts: Tropomyosin receptor kinase B, Moxibustion, Hippocampus, Neurotrophic factors, Brain-derived neurotrophic factor, Internal medicine, Medicine, Receptor