Effect of Ginsenoside Re on Rat Myocardial Ischemia-Reperfusion Apoptosis and Caspase-3

Objective:To investigate the ginsenoside Re on myocardial ischemia-reperfusion apoptosis and Caspase-3 effect.Methods:30 healthy rats were randomly divided into sham operation group,model group,ginsenoside Re treated group,n = 10,modeling of acute myocardial infarction.Re the treatment group before LAD ligation 10min sublingual intravenous Re 30mg/kg.Each group were sacrificed after 6 hours reperfusion,the number of apoptotic cells were detected and Caspase-3 activity.Results:The treatment group ginsenoside Re apoptosis index was significantly lower than model group(P0.05).Determination of Caspase-3 activity and protein expression index lower than the model group(P0.05).Conclusion:Ginsenoside Re in reducing ischemic reperfusion injury induced myocardial apoptosis,but also reduce the expression of Caspase-3.These results suggested that inhibition of ginsenoside Re Caspase-3 expression,may be inhibited ginsenoside Re acute ischemia-reperfusion injury induced by one of the mechanisms of myocardial cell apoptosis.