Effects of Different Doses of Methylprednisolone on Inflammatory Factors and Efficacy in Patients with Acute Respiratory Distress Syndrome

Objective To discuss the effect of different doses of Methylprednisolone on inflammatory factors and efficacy in patients with acute respiratory distress syndrome( ARDS). Methods 60 ARDS patients in our hospital from 2012 to 2013were chosen,and they were randomly divided groups A,B,C,each of 20 cases. All patients were given conventional therapy,group B was given intravenous injection of Methylprednisolone,80 mg /d,group C was given intravenous injection of Methylprednisolone,500 mg /d. All patients treated for 3 days. The levels of C- reactive protein( CRP),fibrinogen( FIB) and procalcitonin( PCT) were detected before treatment,3 days and 7 days after treatment,and oxygenation index,APACHEⅡ score,hospitalization days and mortality were observed. Results Before treatment,there was no significant differences in the levels of CRP,FIB and PCT among the three groups( P 0. 05). 3 days and 7 days after treatment,the levels of CRP,FIB and PCT in groups B and C were lower than those of group A,group C were lower than those of group B( P 0. 05). Before treatment,there was no significant differences in oxygenation index,APACHEⅡ score among the three groups( P 0. 05). After treatment,the oxygenation index in groups B and C was higher than that of group A,group C were higher than that of group B( P 0. 05); APACHEⅡ score were lower than that of group A,group C was lower than that of group B( P 0. 05); hospitalization days and mortality were lower than those of group A( P 0. 05). Conclusion Methylprednisolone can significantly inhibit the inflammatory factor,help to improve the therapeutic effect in patients with ARDS,and the effect of large dose of Methylprednisolone is better.