Evaluation of the Clinical Efficacy of Fluconazole to Sporotrichosis and the Antifungal Susceptibility in Vitro

Objective To investigate the clinical efficacy of fluconazole in the treatment of Sporotrichosis and the susceptibility of fluconazole and itraconazole to Sporothrix schenckii in vitro,to study a new method in the treatment of Sporotrichosis.Methods 60 cases of patients with Sporotrichosis were given fluconazole tablets for three months.As a control,30 patients with Sporotrichosis were given 10%KI for three months.The MIC of fluconazole and itraconazole for 10 isolates of Sporothrix schenckii were determined by the E-test.Results The effective rate of treatment and control group were 95.00% and 86.67% respectively.The MICs of fluconazole and itraconazole tothe 10 clinical isolates determined by the E-test were 256μg/ml and 0.012～8.0μg/ml respectively.Conclusions The studies suggest that fluconazole is an effective method in the treatment of Sporotrichosis.E-test may be a good test for determining antifungal susceptibility of some antifungal agents to Sporothrix schenckii.