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2006•Letters in BiotechnologyRequires access

Embryoid Body Derived from Embryonic Stem Cell as a Model to Study Mouse Early Embryogenesis

Sun Yanxun

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Abstract

It is undisputed that embryonic stem ES cells can differentiate into all cells of the body. When cultured as aggregates embryoid bodies derived from ES cells recapitulate early steps of embryo development in structure including formation of endoderm on the surface of the inner cell mass differentiation of columnar epithelium and formation of central cavity. This review studies mouse development in different stages of early embryo programmed cell death and TGF-β signaling events in this process by the model of embryoid bodies.

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What this paper is about

It is undisputed that embryonic stem ES cells can differentiate into all cells of the body. When cultured as aggregates embryoid bodies derived from ES cells recapitulate early steps of embryo development in structure including formation of endoderm on the surface of the inner cell mass differentiation of columnar epithelium and formation of central cavity. This review studies mouse development in different stages of early embryo programmed cell death and TGF-β signaling events in this process by the model of embryoid bodies.

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Available abstract

It is undisputed that embryonic stem ES cells can differentiate into all cells of the body. When cultured as aggregates embryoid bodies derived from ES cells recapitulate early steps of embryo development in structure including formation of endoderm on the surface of the inner cell mass differentiation of columnar epithelium and formation of central cavity. This review studies mouse development in different stages of early embryo programmed cell death and TGF-β signaling events in this process by the model of embryoid bodies.

Key concepts: Embryoid body, Embryonic stem cell, Cell biology, Endoderm, Embryogenesis, Biology, Embryo, Histogenesis

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