Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats

Objective: To explore the effect of Abelmoschus manihot flavonoids on blood lipids of hyperlipidemic rats.Methods: Totally 100 SD rats were divided randomly into 6 groups: normal control group,high-fat control group,lovastatin positive control group at the dose of 10 mg/(kg·d),and flavonoid groups at low,middle and high doses(3,30 mg/(kg·d) and 90 mg/(kg·d)).Except normal the control group,all groups were fed high-fat diet to establish a hyperlipidemia model.Normal control group and high-fat control group were given distilled water at the dose of 10 ml/(kg·d) once a day for 6 consecutive weeks.Serum TC,TG,HDL-C,LDL-C,and ox-LDL were determined after the last administration.Results: Compared with the control group,serum TC,TG,LDL-C and ox-LDL revealed a significantly reduction in all the model groups.However,no significant difference in HDL-C level was observed among these groups.Conclusion: The flavonoids can delay the formation and development of arteriosclerosis.