ScholarLens Back to search
2004•Journal of Jilin University ofRequires access

Clinical significance of determination of VCAM-1 and TNF-αin serum of patiens with pregnancy-induced hypertension and in cord blood of newborns

Wang Li

Open publisher page 0 citations

Abstract

ObjectiveTo study the role of vascular cell adhesion molecules (VCAM 1) and tumor necrosis factor (TNF α)on the pathogenesis of pregnancy induced hypertension (PIH).MethodsELISA and radioimmunoassay were used to measure the levels of VCAM 1 and TNF α in maternal serum and cord blood of 20 cases of normal pregnant women and 60 cases of PIH women. ResultsThe serum levels of VCAM 1 and TNF α in the moderate and severe PIH group were significantly higher than that in control group ( P 0 05). There was no difference of the levels of VCAM 1 and TNF α in cord blood between PIH and control group. There was significant relativity between VCAM 1 and TNF α in serum of PIH patients ( P 0 05). ConclusionVCAM 1 and TNF α may be important factors in the pathogenesis of PIH.

About this research paper

What this paper is about

ObjectiveTo study the role of vascular cell adhesion molecules (VCAM 1) and tumor necrosis factor (TNF α)on the pathogenesis of pregnancy induced hypertension (PIH).MethodsELISA and radioimmunoassay were used to measure the levels of VCAM 1 and TNF α in maternal serum and cord blood of 20 cases of normal pregnant women and 60 cases of PIH women. ResultsThe serum levels of VCAM 1 and TNF α in the moderate and severe PIH group were significantly higher than that in control group ( P 0 05). There was no difference of the levels of VCAM 1 and TNF α in cord blood between PIH and control group. There was significant relativity between VCAM 1 and TNF α in serum of PIH patients ( P 0 05). ConclusionVCAM 1 and TNF α may be important factors in the pathogenesis of PIH.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

ObjectiveTo study the role of vascular cell adhesion molecules (VCAM 1) and tumor necrosis factor (TNF α)on the pathogenesis of pregnancy induced hypertension (PIH).MethodsELISA and radioimmunoassay were used to measure the levels of VCAM 1 and TNF α in maternal serum and cord blood of 20 cases of normal pregnant women and 60 cases of PIH women. ResultsThe serum levels of VCAM 1 and TNF α in the moderate and severe PIH group were significantly higher than that in control group ( P 0 05). There was no difference of the levels of VCAM 1 and TNF α in cord blood between PIH and control group. There was significant relativity between VCAM 1 and TNF α in serum of PIH patients ( P 0 05). ConclusionVCAM 1 and TNF α may be important factors in the pathogenesis of PIH.

Key concepts: Medicine, VCAM-1, Pathogenesis, Cord blood, Radioimmunoassay, Tumor necrosis factor alpha, Cell adhesion molecule, Pregnancy

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Clinical significance of determination of VCAM-1 and TNF-αin serum of patiens with pregnancy-induced hypertension and in cord blood of newborns — Research Paper | ScholarLens