Detection of sensitization to HLA antigens after liver transplantation

Objective To investigate the sensitization to HLA antigens and relationship between sensitization and allograft function after liver transplantation. Methods The panel reactive antibody (PRA) in serum was determined by using LAT ELISA kit in 15 recipients before and after liver transplantation. Results Moderate sensitization was detected in one of 15 cases before transplantation. The patient experienced one episode of mild rejection, which was reversed by treatment with Methylprednisolone. PRA in this patient maintained positive 3 months posttransplantation. The remaining 14 patients had negative PRA (10 %) before and after surgery. One recipient developed acute rejection, but the PRA was continually negative. Conclusion Sensitization rate in Chinese liver recipients is lower, which might be related to the lower incidence of rejection after liver transplantation.