Effects of simvastatin on acute myocardial infarction with atrial fibrillation after cardioversion

Objectives To investigate the effects of different dosage of simvastatin on acute myocardial infarction with paroxysmal atrial fibrillation. Methods One hundred and thirteen patients of acute myocardial infarction with paroxysmal atrial fibrillation according to different dosage of simvastatin were divided into three groups (group 40 mg,n=35; group 20 mg,n=40; group control,n=38). The effect of lipid-lowering treatment,the recurrence of atrial fibrillation,and the ischemic events were followed up for 6 months. Results 1. In the effect of lipid-lowering treatment,group 40 mg and group 20 mg were superior to group control (P0.05 or 0.01),group 40 mg was superior to group 20 mg (P0.05);2. In the recurrent rate of atrial fibrillation,group 40 mg and group 20 mg were less than group control (P0.05 or 0.01),group 40 mg was less than group 20 mg (P0.05);3. In the rate of ischemic events,group 40 mg and group 20 mg were less than group control (P0.05 or 0.01). Conclusions Simvastatin can lower lipid,decrease the recurrent rate of atrial fibrillation and the rate of ischemic events in patients of acute myocardial infarction with paroxysmal atrial fibrillation. These benefits from simvastatin 40mg were more obvious than from simvastatin 20 mg.