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2004•Chinese Journal of Birth Health & HeredityRequires access

Cytogenetics analysis of 268 couples with spontaneous abortion

Guo Huai

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Abstract

Objective: To analyze the chromosomal karyotypes of 268 couples with spontaneous abortion, to study the relationship between chromosomal abnormality with spontaneous abortion. Methods: Detected chromosomal karyotypes of the patients by culturing peripheral blood lymphocytes,using G-banding techniques. Results: We detected 28 cases of chromosomal abnormalities in 536 patients,the frequency was 5.22%,including 16 cases of balanced translocation、4 cases of Robertsonian translocation、8 cases of pericentric inversion. And 20 cases of chromosome polymorphisms were detected, the frequency was 3.73%(20/536). Conclusion: Chromosomal abnormality is one of the important causes of spontaneous abortion. Chromosome studies on spontaneous abortions have important significance.

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What this paper is about

Objective: To analyze the chromosomal karyotypes of 268 couples with spontaneous abortion, to study the relationship between chromosomal abnormality with spontaneous abortion. Methods: Detected chromosomal karyotypes of the patients by culturing peripheral blood lymphocytes,using G-banding techniques. Results: We detected 28 cases of chromosomal abnormalities in 536 patients,the frequency was 5.22%,including 16 cases of balanced translocation、4 cases of Robertsonian translocation、8 cases of pericentric inversion. And 20 cases of chromosome polymorphisms were detected, the frequency was 3.73%(20/536). Conclusion: Chromosomal abnormality is one of the important causes of spontaneous abortion. Chromosome studies on spontaneous abortions have important significance.

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Available abstract

Objective: To analyze the chromosomal karyotypes of 268 couples with spontaneous abortion, to study the relationship between chromosomal abnormality with spontaneous abortion. Methods: Detected chromosomal karyotypes of the patients by culturing peripheral blood lymphocytes,using G-banding techniques. Results: We detected 28 cases of chromosomal abnormalities in 536 patients,the frequency was 5.22%,including 16 cases of balanced translocation、4 cases of Robertsonian translocation、8 cases of pericentric inversion. And 20 cases of chromosome polymorphisms were detected, the frequency was 3.73%(20/536). Conclusion: Chromosomal abnormality is one of the important causes of spontaneous abortion. Chromosome studies on spontaneous abortions have important significance.

Key concepts: Chromosomal translocation, Chromosomal Abnormality, Abortion, Karyotype, Robertsonian translocation, Chromosomal inversion, Chromosomal rearrangement, Cytogenetics

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