Correlation research between the unilateral MCA stenosis rate and cerebral blood flow MR perfusion-weighted imaging

Objective:To evaluate the correlation between stenosis or occlusion of MCA and the values of the magnetic resonance(MR) perfusion-weighted imaging(PWI).Methods:MR PWI was performed in 30 TIA patients with unilateral stenosis or occlusion of MCA diagnosed by high-resolution MR.The cerebral perfusion parameters including regional cerebral blood volume(rCBV),regional cerebral blood flow(rCBF),regional mean transit time(rMTT) and regional time to peak(rTTP) of both cerebral hemispheres were analyzed.Results:In the 30 patients,unilateral MCA steniosis or occlusion was found by high-resolution MRI and often with abnormal perfusion.The rMTT and rTTP of the involved cerebral hemispheres were significantly increased compared with the contralateral hemispheres in the patients(P0.05),the rCBV and rCBF were significantly reduced(P0.05).The rate of the MCA stenosis showed a positive correlation with the extention percentage rMTT(r=0.45,P0.05).Conclusion:The diagnosis of unilateral MCA stenosis or occlusion by high-resolution MRI showed a positive correlation with PWI,the combination of both can exactly assess the status of blood supply for the cerebral tissues,which is helpful to clinical diagnosis of cerebral ischemia in the patients with unilateral MCA stenosis.