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Mechanism of protective effect of trimetazidine on myocardial injury in diabetic rats

Wei Yu-qiao

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Abstract

Objective To study the effect of caveolin-3 on myocardial damage of Type 1 diabetic rats.Methods 26 SD rats were randomly divided into five groups.These rats were provided streptozotocin(65 mg/kg) by intraperitoneal injection to induce type 1 diabetes.When we got the diabetic rats,ISO(4 mg/kg) was provided through intraperitoneal injection at the fourth day.TMZ(40 mg/kg) was provided through intragastric administration.After 1 week,the CK activities of serum and LDH,MDA and SOD contents were measured,the total protein content of caveolin-3 was analyzed by western blot.Results Compared with the NC group,all the parameters had no significant difference in DM group,DM+TMZ group.Compared with the DM group,CK,LDH,MDA contents were significantly increased(P0.01),and SOD activities were significantly decreased(P0.01,P0.05)in DM+ISO group and DM+ISO+TMZ group;compared between DM+ISO group and DM+ISO+TMZ group,CK,LDH,MDA contents were significantly decreased(P0.01),and SOD activities were significantly increased(P0.05)in DM+ISO+TMZ group.Compared with the DM group,the expression levels of caveolin-3 were significantly decreased(P0.05)in DM+ISO group and DM+ISO+TMZ group,but there were no significant difference between DM+ISO group and DM+ISO+TMZ group.Conclusion TMZ can protect the myocardial damage in diabetic rats.

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What this paper is about

Objective To study the effect of caveolin-3 on myocardial damage of Type 1 diabetic rats.Methods 26 SD rats were randomly divided into five groups.These rats were provided streptozotocin(65 mg/kg) by intraperitoneal injection to induce type 1 diabetes.When we got the diabetic rats,ISO(4 mg/kg) was provided through intraperitoneal injection at the fourth day.TMZ(40 mg/kg) was provided through intragastric administration.After 1 week,the CK activities of serum and LDH,MDA and SOD contents were measured,the total protein content of caveolin-3 was analyzed by western blot.Results Compared with the NC group,all the parameters had no significant difference in DM group,DM+TMZ group.Compared with the DM group,CK,LDH,MDA contents were significantly increased(P0.01),and SOD activities were significantly decreased(P0.01,P0.05)in DM+ISO group and DM+ISO+TMZ group;compared between DM+ISO group and DM+ISO+TMZ group,CK,LDH,MDA contents were significantly decreased(P0.01),and SOD activities were significantly increased(P0.05)in DM+ISO+TMZ group.Compared with the DM group,the expression levels of caveolin-3 were significantly decreased(P0.05)in DM+ISO group and DM+ISO+TMZ group,but there were no significant difference between DM+ISO group and DM+ISO+TMZ group.Conclusion TMZ can protect the myocardial damage in diabetic rats.

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Available abstract

Objective To study the effect of caveolin-3 on myocardial damage of Type 1 diabetic rats.Methods 26 SD rats were randomly divided into five groups.These rats were provided streptozotocin(65 mg/kg) by intraperitoneal injection to induce type 1 diabetes.When we got the diabetic rats,ISO(4 mg/kg) was provided through intraperitoneal injection at the fourth day.TMZ(40 mg/kg) was provided through intragastric administration.After 1 week,the CK activities of serum and LDH,MDA and SOD contents were measured,the total protein content of caveolin-3 was analyzed by western blot.Results Compared with the NC group,all the parameters had no significant difference in DM group,DM+TMZ group.Compared with the DM group,CK,LDH,MDA contents were significantly increased(P0.01),and SOD activities were significantly decreased(P0.01,P0.05)in DM+ISO group and DM+ISO+TMZ group;compared between DM+ISO group and DM+ISO+TMZ group,CK,LDH,MDA contents were significantly decreased(P0.01),and SOD activities were significantly increased(P0.05)in DM+ISO+TMZ group.Compared with the DM group,the expression levels of caveolin-3 were significantly decreased(P0.05)in DM+ISO group and DM+ISO+TMZ group,but there were no significant difference between DM+ISO group and DM+ISO+TMZ group.Conclusion TMZ can protect the myocardial damage in diabetic rats.

Key concepts: Medicine, Trimetazidine, Intraperitoneal injection, Streptozotocin, Internal medicine, Western blot, Diabetes mellitus, Endocrinology

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Mechanism of protective effect of trimetazidine on myocardial injury in diabetic rats — Research Paper | ScholarLens