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Expression of CD_ 21 on Peripheral Blood B Lymphocytes in Children with Infectious Mononucleosis

Wei-Zhang Shou

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Abstract

Objective To investigate the expression of CD_ 21 on peripheral blood B lymphocytes in children with infectious mononucleosis(IM).Methods The expression of CD_ 21 on B lymphocytes were analyzed with flow cytometry in IM group and two control groups.Results The ratio of B lymphocytes,the number of B lymphocytes expressing CD_ 21,and the number of CD_ 21 on B lymphocyte were significantly higher in IM group than two control groups(P0.05,P0.01).Conclusion Infection of Epstein-Barr virus (EBV) could induce B lymphocytes expression CD_ 21 with higher level, and benefit to EBV enter cells and lead to latent and proliferative infection.

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What this paper is about

Objective To investigate the expression of CD_ 21 on peripheral blood B lymphocytes in children with infectious mononucleosis(IM).Methods The expression of CD_ 21 on B lymphocytes were analyzed with flow cytometry in IM group and two control groups.Results The ratio of B lymphocytes,the number of B lymphocytes expressing CD_ 21,and the number of CD_ 21 on B lymphocyte were significantly higher in IM group than two control groups(P0.05,P0.01).Conclusion Infection of Epstein-Barr virus (EBV) could induce B lymphocytes expression CD_ 21 with higher level, and benefit to EBV enter cells and lead to latent and proliferative infection.

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Available abstract

Objective To investigate the expression of CD_ 21 on peripheral blood B lymphocytes in children with infectious mononucleosis(IM).Methods The expression of CD_ 21 on B lymphocytes were analyzed with flow cytometry in IM group and two control groups.Results The ratio of B lymphocytes,the number of B lymphocytes expressing CD_ 21,and the number of CD_ 21 on B lymphocyte were significantly higher in IM group than two control groups(P0.05,P0.01).Conclusion Infection of Epstein-Barr virus (EBV) could induce B lymphocytes expression CD_ 21 with higher level, and benefit to EBV enter cells and lead to latent and proliferative infection.

Key concepts: Mononucleosis, Peripheral blood, Flow cytometry, Immunology, Lymphocyte, Epstein–Barr virus, Biology, Atypical Lymphocyte

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