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Advances in the Research of ERK5 MAPK Signaling Transduction

Muo Baoqing

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Abstract

MAPK signaling transduction is a key pathway of cellular proliferation and apoptosis regulation. The abnormality of the pathway is related to many tumor and proliferative diseases. So MAPK can serves as a molecular target for diseases treatment. Four pathways of MAPK signaling transduction have been identified at present; ERK1/2, JNK, P38 and ERK5, among which ERK5 MAPK signaling transduction is a relatively new one. This article reviews the advances in the research of features, functions and of ERK5 MAPK signaling transduction and its relationship with human diseases.

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What this paper is about

MAPK signaling transduction is a key pathway of cellular proliferation and apoptosis regulation. The abnormality of the pathway is related to many tumor and proliferative diseases. So MAPK can serves as a molecular target for diseases treatment. Four pathways of MAPK signaling transduction have been identified at present; ERK1/2, JNK, P38 and ERK5, among which ERK5 MAPK signaling transduction is a relatively new one. This article reviews the advances in the research of features, functions and of ERK5 MAPK signaling transduction and its relationship with human diseases.

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Available abstract

MAPK signaling transduction is a key pathway of cellular proliferation and apoptosis regulation. The abnormality of the pathway is related to many tumor and proliferative diseases. So MAPK can serves as a molecular target for diseases treatment. Four pathways of MAPK signaling transduction have been identified at present; ERK1/2, JNK, P38 and ERK5, among which ERK5 MAPK signaling transduction is a relatively new one. This article reviews the advances in the research of features, functions and of ERK5 MAPK signaling transduction and its relationship with human diseases.

Key concepts: Signal transduction, MAPK/ERK pathway, Transduction (biophysics), Biology, Cell biology, Mitogen-activated protein kinase, Biochemistry

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