Clinical Evaluation of the Response of Patients with Septic Shock to Early Fluid Resuscitation

Objective To study the clinical response to early fluid resuscitation therapy in septic shock patients.Methods Thirty-eight septic shock patients received early goal-directed therapy(EGDT) in the ICU of our hospital from February 2008 to February 2010.The patients were divided into survival group(n=21) and dead group(n=17).Indexes like central venous pressure(CVP),heart rate(HR),mean arterial pressure(MAP),fluid input,urine output,and blood lactate were evaluated.Results Six hours after the EGDT,the results for the patients were all up to standard.There were 21 cases of survival(55.26%) and 17 cases of death(44.74%).The total fluid input and liquid types were similar in the two groups(P0.05).The urine output and lactate clearance at hour 6 and 24 for the survival group were better than that for the dead group(P0.05).Conclusion The lactate clearance and urine output can be regarded as an surveillance indicator of fluid resuscitation for patients with septic shock.