New Experimental Model of Allergic Rhinitis of Rat

Objective: To develop an experimental animal model of allergic rhinitis in rats. Methods: Generally sensitized rats were received repeated local booster sensitization into nasal cavity. The severity of allergic rhinitis was determined by two nasal allergic symptoms (sneezing and nasal rubbing), and the levels of IgE were assessed by PCA titers. Results: The numbers of sneezing and nasal rubbing were markedly increased and at the meantime, the levels of IgE were also markedly elevated by intranasal sensitization. Ketotifen and astemizole inhibited significantly the antigen induced nasal symptoms with a dose dependent mode. Conclusion: The allergic rhinitis model is very useful for evaluating the effects of drugs for Ⅰ type allergic rhinitis.