Expression of CD105, COX-2 and VEGF and Their Relationship with Angiogenesis in Colorectal Carcinoma

Objective To investigate the expression CD105 in newborn vessel of COX-2 and VEGF in colorectal carcinoma and their relationship with angiogenesis.Methods Immunohistochemical staining (S-P method) for CD105, COX-2 and VEGF was performed in 58 cases of colorectal carcinoma; the microvessel density (MVD) was marked by CD105.Results The value of MVD with marked CD105 was (36.50±9.59), the positive rate of COX-2 and VEGF were respectively 69% and 67.2%. The MVD in COX-2 positive group or VEGF positive group was significantly higher than that in COX-2 negative group or VEGF negative group(P0.01). The MVD in the group of both COX-2 and VEGF positive was significantly higher than that in both negative groups. There was a significant positive correlation between the expression of COX-2 and VEGF.Conclusion CD105 was a specific marker of newborn vessel in colorectal carcinoma; COX-2 was correlated to angiogenesis and VEGF may be an important mediator in this process.