Clinical Observation of Shenluotong for Treatment of IgA Nephropathy Patients with Prevailing Proteinuria

Objective To investigate the therapeutic effects of a self-made prescription Shenluotong in treating IgA nephropathy patients with clinical presentation of prevailing proteinuria.Methods Totally 120 IgA nephropathy patients whose main clinical presentation was proteinuria were randomly divided as trial and control groups.The patients were given,besides the basic treatment,Shenluotong in the trial group,and Lotensin in the control group for 12 months.The effects,symptom scores in Chinese medicine,and indices of glomerular filtration rate (GFR),serum creatinine (Scr),quantity of 24 h urinary protein,and plasma albumin (ALB) were observed before and after the treatment.Results The trial group was better than the control group in effect (P0.01);and so was in symptom score after treatment (P0.01).After treatment the quantity of 24 h urinary protein was decreased and ALB level was increased in the trial group (P0.05);and there were significant differences as compared with the control group (P0.05).Conclusion The Shenluotong can improve the symptom,reduce proteinuria,and protect renal function for IgA nephropathy patients.