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2007•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Determination of Protocatechuic Aldehyde in Weishukang Granules by HPLC

Bao Wang

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Abstract

Aim To establish a method for the determination of protocatechuic aldehyde in Weishukang granules.Methods RP-HPLC method was developed for the determination of protocatechuic aldehyde in Weishukang granules on the Japanese Sil C18 column,with methanol-1% acetic acid(13∶87)as a mobile phase(1ml/min)and detection wavelength at 280 nm.Results The linear range of Protocatechuic aldehyde was 0.076 2～0.457 2μg and the correlation coefficient was 0.999 9.The average recovery rate was 100.6%,and RSD was 0.88%(n=6).Conclusion The method is convenient,accurate and can be used to control the quality of granules.

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What this paper is about

Aim To establish a method for the determination of protocatechuic aldehyde in Weishukang granules.Methods RP-HPLC method was developed for the determination of protocatechuic aldehyde in Weishukang granules on the Japanese Sil C18 column,with methanol-1% acetic acid(13∶87)as a mobile phase(1ml/min)and detection wavelength at 280 nm.Results The linear range of Protocatechuic aldehyde was 0.076 2～0.457 2μg and the correlation coefficient was 0.999 9.The average recovery rate was 100.6%,and RSD was 0.88%(n=6).Conclusion The method is convenient,accurate and can be used to control the quality of granules.

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Available abstract

Aim To establish a method for the determination of protocatechuic aldehyde in Weishukang granules.Methods RP-HPLC method was developed for the determination of protocatechuic aldehyde in Weishukang granules on the Japanese Sil C18 column,with methanol-1% acetic acid(13∶87)as a mobile phase(1ml/min)and detection wavelength at 280 nm.Results The linear range of Protocatechuic aldehyde was 0.076 2～0.457 2μg and the correlation coefficient was 0.999 9.The average recovery rate was 100.6%,and RSD was 0.88%(n=6).Conclusion The method is convenient,accurate and can be used to control the quality of granules.

Key concepts: Chromatography, Protocatechuic acid, Chemistry, High-performance liquid chromatography, Aldehyde, Linear correlation, Acetic acid, Methanol

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