Effect of Kun'an Granule on Serum Hormone Level in Rats with Hyperprolactinemia

[Objective] To investigate the effect of Kun'an Granule (KG) on serum hormone level in rats with hyperprolactinemia [ Methods ] Rats were randomized to five groups: group A ( mimic operation) , group B (model control), group C (bromocriptine), group D (low-dose KG) and group E (high-dose KG). Except group A, the other four groups were implanted with pituitary for modeling. Group C was treated with bromocriptine 1 mg/kg, group D with gastric infusion of KG 4 g/kg and group E with KG 12 g/kg. The treatment lasted 34 days. Serum levels of prolactin (PRL), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estrogen (E2) were detected before and after treatment and the differences between groups were compared. [ Results ] Serum PRL and T levels were increased and LH, FSH and E2 levels decreased in group B (P 0.05 or P 0.01 compared with group A). Serum PRL and T levels were decreased and LH, FSH and E2 levels increased in groups C, D and E to some extent (P 0.05 or P 0.01 compared with group B). [Conclusion] KG can regulate the serum hormone levels in rats with hyperprolactinemia by decreasing PRL and T levels and by increasing LH, FSH and E2 levels.