2013•Science and Technology of Food IndustryRequires access

Ganoderic acid Me improves the sensitivity of multidrug resistant KB-A-1/Dox cells to doxorubicin

Tang We

Abstract

The effect and primary mechanism of multidrug resistance reverse of cancer cell to Doxorubicin by ganoderic acid Me(GA-Me) was studied.The results showed that GA-Me possessed the cytotoxicity and induced the apoptosis of multidrug resistant cancer cells and sensitive cancer cells under high concentration dose- dependently.The cytotoxicity of doxorubicin on multidrug resistant cancer cells increased by 5μg /mL of GA- Me treatment,this result indicated that GA-Me could reverse the multidrug resistance of cancer cells to doxorubicin.Moreover,the content of doxorubicin and Rhodamin123 in multidrug resistance cancer cells increased 100% respectively by GA-Me treatment.This result indicated that GA- Me might be influence the activity of membrane protein P-gp.The results mentioned above showed that GA- Me could reverse the multidrug resistance of cancer cells to doxorubicin by influence of membrane protein P- gp and induction of apoptosis.The results in this paper provided the theoretical foundation for development of functional food and leading compounds for cancer therapy.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Doxorubicin, Multiple drug resistance, Apoptosis, Cancer cell, Cytotoxicity, Cancer, Pharmacology, Cancer research