Risk factors of recurrent colorectal adenomas after resection

Objective: To study risk factors of recurrent colorectal adenomas after resection.Methods: Colorectal adenoma patients were collected and divided into observation group with recurrence and control group without recurrence.Then general status and expression of Cox-1,Cox-2 were compared.Results: Less patients had regular diet compared with control group,and they were ≥40 years old in observation group.More patients had family history,smoking history,drinking history and anxiety and depression in observation group.Cox-2 mRNA and protein levels were significantly higher than control group.Cox-2 content was positively correlated with age,family history,smoking history,drinking history and spirit,and negatively correlated with diet.Conclusions: Age,family history,smoking history,drinking history,mental state,diet may affect recurrence of colorectal adenomas by affecting the expression of local Cox-2.