Effects of perindopril and fosinopril therapy on congestive heart failure and proinflammatory cytokines

Objective: This study was to compare perindopril and fosinopril in improvement of quality of life and decrease of proinflammatory cytokines in patients with congestive heart failure (CHF), evaluate the therapeutic efficiency and safety of the two drugs. Methods: The 87 patients with CHF were randomized divided into perindopril group (n = 30), fosinopril group (n = 29) and control group (n = 28). Serum TNFα、 IL -6、 IL-1β、 Cr、 BUN、 K+、 SV、 CO、 LVEF were measured before treatment and after treatment 4 weeks. 6MWT, MLWHF were examined in same time. Results: After treatment 4 weeks, IL -6 level and MLWHF of two groups decreased (P0. 01 all). SV, CO, LVEF and 6 MWT of two groups increased (P0. 01-0. 001). TNF### level decreased (P0. 05) in fosinopril group. Conclusion: Both perindopril and fosinopril can decrease proinflammatory cytokine and improve the quality of life in CHF patients. In some parameters, fosinopril have the dominance (example decrease TNFα).