Evaluation of the pharmacokinetics of dexibuprofen modified-release capsules in Beagle dog

Objective To develop a rapid and specific HPLC-UV method for the determination of dexibuprofen in Beagle dog plasma,and use it to investigate the pharmacokinetics of dexibuprofen in Beagle dog plasma.Method A single dose,two periods,cross-over study in 8 Beagle dogs was carried out.After an oral dose of dexibuprofen modified-release capsules (test) or Qingfen tablets (reference),the plasma samples were drawn and analyzed.Results There were no significant difference in AUC 0-t and AUC 0-∞ between the two preparations,but ρ max of the test preparation was less than the reference one and t max was obviously larger than it.Conclusion The release of the test preparation dexibuprofen modified-release capsules is modified.