The therapeutic effect of FLAG regime for refractory or relapsed acute leukemia

Objective To investigate the efficacy and side effects of the regimen combined with fludarabine,cytarabine and filgrastim(FLAG)for refractory or relapsed patients with acute leukemia(AL).Methods A total of 20 patients with AL were enrolled to treat with FLAG regimen,then observed the efficacy and side effects.Fludarabine 50 mg/d,intravenous drip(VD) lasts 30 min 1-5 days.Cytarabine 0.5―1.0 g/m(2) on day 1,every 12 hours at a time,after the fludarabine 4 h,VD,1-5 days.Filgrastim 300 μg/d,subcutaneous injection(fludarabine before 1 h,0-5 days).Results The rate of CR,PR and OR was 55%,20% and 75% respectively.71.8% of CR occurred after the first course with such regimen.There were no disparities between the groups of ALL,AML and MAL(P0.05).The main side effects were severe myelosuppression and infection due to neutropenia.But mostly patients could be recovered after treatment during the intermission.Conclusion FLAG regimen is effective and well-tolerated treatment for patients with refractory and relapsed acute leukemia,especially for younger patients.It is one of the prefered regimens to treat refractory or relapsed acute leukemia.