2013•China Modern MedicineRequires access
The observation of adefovir dipivoxi l in combination with lamivudine therapy for HBeAg positive chronic hepatitis B in 49 cases
XU Qingtian
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Abstract
Objective To investigate the efficacy of adefovir dipivoxil in combination with lamivudine therapy for HBeAg positive chronic hepatitis B.Methods Forty nine cases of HBeAg positive naive patients were given adefovir dipivoxil combined with lamivudine.The changes of ALT,HBeAg and HBVDNA in the patients were observed for 96 weeks.Results After 12 weeks,24 weeks,48 weeks and 96 weeks of treatment,HBeAg seroconversion rate were 10.20%,24.49%,32.65% and 40.82% ;HBVDNA negative rate were 46.94%,65.31%,71.43% and 81.63% ;ALT normalization rate were 48.98%,69.39%,73.47% and 79.59% respectively.Conclusion The results of initial adefovir dipivoxil combined with lamivudine treatment for HBeAg positive chronic hepatitis B patients is satisfactory,and drug resistance is low.