Efficacy of vaccination of hepatitis B vaccine in Newborns

OBJECTIVE To observe the efficacy of vaccination of hepatitis B vaccine in the newborn,so as to provide reference for prevention of hepatitis B.METHODS Totally 1187infants aged from 0to 3years old,who recieved hepatitis B vaccination in the hospital from May 2009 to Aug 2012,were divided into 0years group(1years old,276cases),1year group(1-2year old,302cases),2years group(2-3years old,298cases)and 3years group(3years old,311cases).ELISA method was used to detect hepatitis B virus surface antigen(HBsAg)and hepatitis B virus surface antibody(anti-HBs)in serum of the neonates,and the immunities of the different age groups of neonates were compared.RESULTS The average positive rate of anti-HBs in the neonates was 84.08%,and the positive rate of the anti-HBs was 94.5%in the less than 1year group.87.75%in the 1-2years old groups,81.54%in the 2-3years old group,73.63%in the more than 3years group.The average positive rate of HBsAg was0.34%,and the rate of the four groups were 0,0,0.34%,and 0.96%,respectively.CONCLUSION The vaccinated neonatal hepatitis B vaccine immune level began to decrease with age.So the detection of hepatitis B serum markers for children older than 3years old is necessary,and prevention measures of hepatitis B should be take in timely manner.