Chinical features,bone marrow smears and bone marrow biopsy of 79 patients with myelodysplastic syndrome-RA

Objective:To study the changes of clinical features,bone marrow smears and bone marrow biopsy of Myelodysplastic Syndrome-RA(MDS-RA) in order to provide value for the diagnosis of questionable cases.Method:The MDS-RA data were selected from the mylodysplastic syndrome data in the last few years and statistical analysed.Result:In clinical features,we found that there were more patients with two or three lineage cytopenia;49% of patients had normoblast and 44% of patients had leucocyte abnormal changes.In bone marrow smears,we found that there were more patients with active hyperplasia and hypoplasia,and dyshaematopoiesis accounted for 83%(66/79).In bone marrow biopsy,we found that there were more patients with active hyperplasia;there were 32 patients(41%) with increased granulocyte precursor cells,56 patients(71%) with abnormal location of immature precursor(ALIP);and development of normoblasts was stopped,so there were 58 patients(73%) with proerythroblast and normoblast island,56 patients(71%) with abnormal megakaryocytes,and 72 patients(91%) with increased fibrous tissues.Conclusion:Bono marrow biopsy is an essential method for the diagnosis of MDS-RA.