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Antiviral Effects of Recombinant Cyanovirin-N on Herpes Simplex Virus Type 2

Yu Hong

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Abstract

Objective To explore the antiviral effect and mechanism of the recombinant CV-N on her- pes simplex virus type 2 (HSV-2).Methods CV-N in various concentrations was applied to different stages of HSV-2 replication cycle.Finally,the cytotoxic effect,cytopathic effect (CPE) and MTT colorimetric assay vital cell rate were used as markers to evaluate the effect of CV-N on HSV-2.Results CV-N had little cy- totoxic effect on Vero cells,it could not directly inactivate HSV-2 infectivity.CV-N not only interfered in ad- sorption of HSV-2 to Vero cells but also inhibited HSV-2 biosynthesis in the cells,which were more effective than the positive control Acyclovir.Conclusion CV-N exhibited pronounced antiviral activities agaist HSV-2.

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What this paper is about

Objective To explore the antiviral effect and mechanism of the recombinant CV-N on her- pes simplex virus type 2 (HSV-2).Methods CV-N in various concentrations was applied to different stages of HSV-2 replication cycle.Finally,the cytotoxic effect,cytopathic effect (CPE) and MTT colorimetric assay vital cell rate were used as markers to evaluate the effect of CV-N on HSV-2.Results CV-N had little cy- totoxic effect on Vero cells,it could not directly inactivate HSV-2 infectivity.CV-N not only interfered in ad- sorption of HSV-2 to Vero cells but also inhibited HSV-2 biosynthesis in the cells,which were more effective than the positive control Acyclovir.Conclusion CV-N exhibited pronounced antiviral activities agaist HSV-2.

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Available abstract

Objective To explore the antiviral effect and mechanism of the recombinant CV-N on her- pes simplex virus type 2 (HSV-2).Methods CV-N in various concentrations was applied to different stages of HSV-2 replication cycle.Finally,the cytotoxic effect,cytopathic effect (CPE) and MTT colorimetric assay vital cell rate were used as markers to evaluate the effect of CV-N on HSV-2.Results CV-N had little cy- totoxic effect on Vero cells,it could not directly inactivate HSV-2 infectivity.CV-N not only interfered in ad- sorption of HSV-2 to Vero cells but also inhibited HSV-2 biosynthesis in the cells,which were more effective than the positive control Acyclovir.Conclusion CV-N exhibited pronounced antiviral activities agaist HSV-2.

Key concepts: Vero cell, Herpes simplex virus, Cytopathic effect, Virology, Recombinant DNA, Infectivity, Cytotoxic T cell, HSL and HSV

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