Effect of Ruhuang preparation on endotoxin and intestinal defence function of cirrhotic rats

Objective: To study the influence of Ruhuang(Rhubarb and Lactohacillin) preparation to endotoxin and intestinal defence function of cirrhotic rats.Methods:88 male Wister rats were randomly divided into normal group,model group,prevention group,prevention of control group,model treatment group and model treatment of control group.Liver cirrhosis model was induced by CCl4 combined with other factors,Ruhuang preparation was used for the prevention and treatment,lactulose was used as positive control drug.The level of plasma endotoxin,intestinal mucosal S-IgA and serum D-lactic acid were detected.Results : The blood plasma endotoxin level of Ruhuang prevention group and model treatment group is lower than that of model group obviously(P0.05);the intestinal mucosal S-IgA level of prevention group is higher than that of model group significantly(P0.05);the blood serum D-lactic acid level of Ruhuang prevention treatment group is lower than that of model cirrhosis group obviously(P0.05),the model treatment group is situated between prevention group and model cirrhosis group.Conclusion:Ruhuang preparation is able to improve intestinal immune function of cirrhostic rats,prevent increasing intestinal permeability,effectively protect intestinal mucosa,balance the intestinal flora,and reduce the occurrence of intestinal endotoxemia in cirrhostic rats.