THE CORRELATIONAL RESEARCH OF NF-ΚB AND HYPOXIA ISCHEMIA REPERFUSION BRAIN INJURY OF NEWBORN RATS WITH ASPHYXIA

[Objective]To observe the activation of NF-κB in hypoxia ischemia reperfusion brain injury of newborn rats with asphyxia.To explore the effect of NF-κB signal pathway on brain injury of newborn with asphyxia.[Methods]The newborn rats(7 days old) were randomly divided into control group(A) and asphyxia group(B) .The model of asphyxia was induced in B group,immunohisto-chemical method was used to detect the activity of NF-κB P65 in the brain of the newborn rats,and hematoxylin-eosin staining was per-formed to observe the histological evidence of asphyxia in the brain.[Results]The activity of NF-κB P65 was higher in group B than that in group A(P﹤0.05) ,increased to the highest peak at 5th day,with nerve cell death and apoptosis in group B.[Conclusion]The NF-κB may play an important role in brain injury with asphyxia.