Effects of combined therapy with losartan and hydrochlorothiazide in hypertensive patients with hyperuricemia

Objective:To evaluate the effects of losartan and hydrochlorothiazide combination therapy on blood pressure and serum uric acid levels in hypertensive patients with hyperuricemia.Methods:A cohort of 55 patients with hypertension and hyperuricemia whose blood pressures uncontrolled with losartan(100 mg/d)for more than 4 weeks were enrolled in this study.All patients were prescribed combination therapy of losartan(50 mg/d)and hydrochlorothiazide(12.5 mg/d)for12 weeks.Blood pressures and serum uric acid levels were determined before and after adjustments to the therapy. Results:After losartan and hydrochlorothiazide combination therapy,mean systolic and mean diastolic pressures decreased significantly,which were(148±11)mmHg vs.(133±14)mmHg and(91±8)mmHg vs.(84±9)mmHg(P0.001),and no significant change in serum uric acid levels was observed at the end of the treatment. Conclusion:For hypertensive patients with hyperuricemia,combination of losartan and hydrochlorothiazide is more effective in reducing blood pressure than losartan single treatment and has no significant influence on serum uric acid levels.