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2010•Chinese Journal of Modern Drug ApplicationRequires access

Clinical study of antiviral effects of Entecavir in patients with chronic Hepatitis B

Wang Da-gu

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Abstract

Objective To study the antiviral effects of Entecavir in patients with chronic Hepatitis B.Methods 49 patients with no prior history of antiviral therapy were randomly assigned to receive Entecavir tablet (0.5 mg) or Lamivudine tablet (100 mg) qd.ALT normalization、HBV-DNA level were assessed during the following 12、24 weeks.if HbeAg(+)at baseline for HbeAg sero conversion cumulative proportions of all-treated patients who ever achieved these responses were also analyzed.Results After 12 weeks,ALT normalization、HBV-DNA level in the treat group was significantly higher than in the control group (P0.05),there was no difference in two groups for HBeAg sero conversion(P0.05).after 24 weeks,HBeAg sero conversion in the treat group was significantly higher than in the control group (P0.05).Conclusion Entecavir is more effective in inhibiting reproduction of HBV than that of Lamivudine.

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What this paper is about

Objective To study the antiviral effects of Entecavir in patients with chronic Hepatitis B.Methods 49 patients with no prior history of antiviral therapy were randomly assigned to receive Entecavir tablet (0.5 mg) or Lamivudine tablet (100 mg) qd.ALT normalization、HBV-DNA level were assessed during the following 12、24 weeks.if HbeAg(+)at baseline for HbeAg sero conversion cumulative proportions of all-treated patients who ever achieved these responses were also analyzed.Results After 12 weeks,ALT normalization、HBV-DNA level in the treat group was significantly higher than in the control group (P0.05),there was no difference in two groups for HBeAg sero conversion(P0.05).after 24 weeks,HBeAg sero conversion in the treat group was significantly higher than in the control group (P0.05).Conclusion Entecavir is more effective in inhibiting reproduction of HBV than that of Lamivudine.

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Available abstract

Objective To study the antiviral effects of Entecavir in patients with chronic Hepatitis B.Methods 49 patients with no prior history of antiviral therapy were randomly assigned to receive Entecavir tablet (0.5 mg) or Lamivudine tablet (100 mg) qd.ALT normalization、HBV-DNA level were assessed during the following 12、24 weeks.if HbeAg(+)at baseline for HbeAg sero conversion cumulative proportions of all-treated patients who ever achieved these responses were also analyzed.Results After 12 weeks,ALT normalization、HBV-DNA level in the treat group was significantly higher than in the control group (P0.05),there was no difference in two groups for HBeAg sero conversion(P0.05).after 24 weeks,HBeAg sero conversion in the treat group was significantly higher than in the control group (P0.05).Conclusion Entecavir is more effective in inhibiting reproduction of HBV than that of Lamivudine.

Key concepts: Entecavir, Lamivudine, HBeAg, Medicine, Chronic hepatitis, Internal medicine, Gastroenterology, Significant difference

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