The Multiplicitive Roles of Reactive Nitrogen Metabolites on Leukemia

Reactive nitrogen metabolites (RNM) are a series of high reactive nitrogen intermediate,which are catalyzed by nitrogen monoxidum synthase(NOS)of cells producing in metabolic process.Their reactive oxidation and nitration are more powerful than those for reactive oxygen metabolites (ROM).RNM participate in the development of multi-species diseases by kinds of channels.It has indicated that reactive nitrogen metabolites not only participate in the development of leukemia,but also educe different effects in the therapy.This article reviewed the multiplicitive roles of the reactive nitrogen metabolites on leukemia.