Investigation of the Efficacy of Recombinant Human Interleukin-II in Combination with Vincristine in Hormone Invalid Idiopathic Thrombocytopenic Purpura

Objective The purpose of this study is To investigate the Clinical efficacy and safety of recombinant human interleukin-Ⅱ combined with vincristine in hormone invalid idiopathic thrombocytopenic purpura.Methods 112 patients with hormone invalid idiopathic thrombocytopenic purpura in our hospital from December 2008 to December 2011 were randomly divided into control group and observation group.Patients in the control group were treated with vincristine.Patients in the observation group were treated with recombinant human interleukin-Ⅱ combined with vincristine.The efficacy and side effect were analyzed in the control group and observation group.Results The total efficient rate was higher in the observation group than control group(85.71% vs 69.64%,P0.05).Side effect were no significant differences in the control group and observation group(P0.05).Conclusion Recombinant human interleukin-Ⅱ combined with vincristine obtained satisfactory efficacy and safety for hormone invalid idiopathic thrombocytopenic purpura.It is worth expanding in hospitals of regional basic-level economic conditions