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2010•Medical Journal of Chinese People's HealthRequires access

Ziprasidone and Quetiapine in the treatment of women schizophrenia

Fang Chuan-rong

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Abstract

Objective:To compare the efficacy and safety of Ziprasidone and Quetiapine in the treatment of women schizophrenia.Methods:94 women patients with schizophrenia were stochastic allocated to two groups treated with Ziprasidone and Quetiapine for 8 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Side Effect Scale were used to evaluate the efficacy and side effects.Results: The significant efficacy rates of Ziprasidone was 82.98% and the efficacy rates was 95.74% after 8 weeks,while that was 80.85% and 93.62% in Quetiapine group.There was no significant difference between the two groups(P0.05).The incidence rate of adverse effect was 23.40% in Ziprasidone group and that was 25.53% in Quetiapine group,and there was not a significant difference between them(P0.05).The level of PRL in Ziprasidone was lower than that of Quetiapine.Conclusions: Ziprasidone is as effective as Quetiapine in the treatment of women schizophrenia,but Ziprasidone was more suitable for women patients.

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What this paper is about

Objective:To compare the efficacy and safety of Ziprasidone and Quetiapine in the treatment of women schizophrenia.Methods:94 women patients with schizophrenia were stochastic allocated to two groups treated with Ziprasidone and Quetiapine for 8 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Side Effect Scale were used to evaluate the efficacy and side effects.Results: The significant efficacy rates of Ziprasidone was 82.98% and the efficacy rates was 95.74% after 8 weeks,while that was 80.85% and 93.62% in Quetiapine group.There was no significant difference between the two groups(P0.05).The incidence rate of adverse effect was 23.40% in Ziprasidone group and that was 25.53% in Quetiapine group,and there was not a significant difference between them(P0.05).The level of PRL in Ziprasidone was lower than that of Quetiapine.Conclusions: Ziprasidone is as effective as Quetiapine in the treatment of women schizophrenia,but Ziprasidone was more suitable for women patients.

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Available abstract

Objective:To compare the efficacy and safety of Ziprasidone and Quetiapine in the treatment of women schizophrenia.Methods:94 women patients with schizophrenia were stochastic allocated to two groups treated with Ziprasidone and Quetiapine for 8 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Side Effect Scale were used to evaluate the efficacy and side effects.Results: The significant efficacy rates of Ziprasidone was 82.98% and the efficacy rates was 95.74% after 8 weeks,while that was 80.85% and 93.62% in Quetiapine group.There was no significant difference between the two groups(P0.05).The incidence rate of adverse effect was 23.40% in Ziprasidone group and that was 25.53% in Quetiapine group,and there was not a significant difference between them(P0.05).The level of PRL in Ziprasidone was lower than that of Quetiapine.Conclusions: Ziprasidone is as effective as Quetiapine in the treatment of women schizophrenia,but Ziprasidone was more suitable for women patients.

Key concepts: Ziprasidone, Quetiapine, Schizophrenia (object-oriented programming), Medicine, Positive and Negative Syndrome Scale, Significant difference, Psychiatry, Internal medicine

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