Effects of Hedan tablet on the ALT,AST in serum and morphological in atherosclerosis rats

Objective To investigate the effects of Hedan tablet on liver function in atherosclerosis model rats.Methods Normal rats were fed with high lipid feedstuff to set up atherosclerosis rat model.The test rats were randomly divided into normal group atherosclerosis model group,medium and high dose group of Hedan tablet,positive control group of Ganle.The liver function indexes in rats of each group were determined.Results Compared with normal group,ALT and AST in model group had significantly increased(P 0.01).After 12 weeks treated with different doses of Hedan tablet compared with model group,ALT and AST had decreased significantly(P0.01) without a dose-dependent manner.Compared with model group,morphological change of fatty liver disease which observed under microscope of the Hedan tablet group had decreased.Conclusion Hedan tablet can relieve liver injury and improve liver function obviously in atherosclerosis rats.