Antiviral effects of entecavir in patients with hepatitis B virus-induced decompensated liver cirrhosis

Objective To analyse antiviral effects of entecavir(ETV) in patients with HBV-induced decompensated cirrhosis.Methods 80 cases were randomly divided into entecavir group(n=40) and adefovir group(n=40) for 48 weeks.HBV DNA,liver function and Child-Pugh scores were observed at different time points.Results At week 4,mean reduction of HBV DNA was 2.26 lgIU/ml,50.0% of the patients achieved undetectable HBV DNA and 30.0% achieved ALT normalization in ETV group.At week 4,12,24,48,the differences of mean reduction of HBV DNA,undetectable HBV DNA and ALT normalization were statiscally significant between the two groups,respectively.The difference of HBeAg negative conversion rates and the HBeAg seroconversion at week 24,48 were significance between the two groups,respectively.The differences of the improvement of Child-Pugh scores were statistically significance between the two groups.Conclusion Entecavir therapy can delay the progression of cirrhosis and has low drug-resistance rates and the safety.