RELATIONSHIP BETWEEN THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME AND NEONATAL HYPOXIA

Objective To explore the relationship between systemic inflammatory response syndrome (SIRS) and neonatal hypoxia, and to evaluate the influence of SIRS to prognosis. Methods Two hundred and seventy-seven cases of newborns with the history of asphyxia and hypoxia were collected. The morbidity, manifestation, prognosis of SIRS in hypoxic group and hypoxia combined infection group were compared and analyzed. In different hypoxic degree, incidence and outcome of SIRS were compared and those between hypoxic group and hypoxia combined infection group were also. Results The more severe the hypoxia was the more incidence of the SIRS would be. In severe asphyxia group, the incidence of SIRS was 39.3%, and in severe asphyxia combined infection group that was65.0%(X2=6.36,u=1,p0.05).In SIRS group, the mortality and incidence of multiple organs dysfunction syndrome(MODS) were much higher than those in non-SIRS group (X2=109.22,u=3,p0.005).The newborns whose manifestations were more consistent with the four diagnostic criteria of SIRS would have the higher incidence of MODS and mortality. By using the diagnostic criteria of severe SIRS evaluates prognosis, the distinction of prediction in severe SIRS was 92.0%, and the positive value of prediction was 56.5%.Conclusion The episode of SIRS can be observed in neonate. The morbidity of SIRS is decided by the quantity and severity of the provocative factors. SIRS is relative to the incidence of MODS and mortality. To a certain extent, the rate of conformity in four diagnostic criteria of SIRS can predict the outcome. Our adoption of severe SIRS criteria can improve the accuracy about prediction of outcome.