EXPERIMENTAL OBSERVATION ON GERMICIDAL EFFICACY AND TOXICITY OF A STABLE CHLORINE DIOXIDE DISINFECTANT

Objective To observe the germicidal efficacy and toxicity of a stable chlorine dioxide disinfectant.Methods Suspension quantitative germicidal test and animal toxicity test methods were used to carry out experimental study.Results The average killing logarithm values of Escherichia coli and Staphylococcus aureus in suspension exposed to the disinfectant solution containing chlorine dioxide 29 mg/L for 2.5 min were 5.00;the average killing logarithm value of Candida albicans was 4.00.Wiping disinfection with the disinfectant solution containing chlorine dioxide 38 mg/L on the surface of table,counter,doors,and carts with a contact time of 5 min killed the natural bacteria by a logarithm value 1.29 in average.The mouse acute oral toxicity LD50 of the disinfectant at the concentration 5 times the applied concentration was greater than 20000 mg/kg·bw.Mouse bone marrow polychromatic erythrocyte micronucleus test was negative.Conclusions The stable chlorine dioxide disinfectant has good germicidal efficacy,and is actually non-toxic.